AFP gene hepatocellular carcinoma vaccine

Definition / meaning of AFP gene hepatocellular carcinoma vaccine

A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as a specific immunologic target for hepatocellular carcinoma. This agent exerts an antitumor effect by inducing cytotoxic T-lymphocytes to attack AFP-expressing tumor cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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