aberrant crypt foci

Definition / meaning of aberrant crypt foci

Clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called ACF.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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