6-azauridine

Definition / meaning of 6-azauridine

A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di-, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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