3-deazauridine

Definition / meaning of 3-deazauridine

A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells..

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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