3′-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine

Definition / meaning of 3′-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine

A hapten-carrier immunoconjugate composed of the hapten trans-3′-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3′-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is notimmunogenic, must be haptenized and conjugated to a carrierprotein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminiumhydroxide may be used as an adjuvant for this vaccine.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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