1-methyl-d-tryptophan

Definition / meaning of 1-methyl-d-tryptophan

A methylated tryptophan with anti-immunosuppressive activity. 1-methyl-d-tryptophan inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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