MedicalTerminology DB
General Medical Terms

pelitrexol

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1 Definition of pelitrexol

Meaning of pelitrexol: A water soluble antifolate with anti-proliferative activity.

A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation.

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