MedicalTerminology DB
Clinical Research & Statistics

historical control subject

Meaning of historical control subject: An individual treated in the past and used in a comparison group when researchers analyze the results of a clinical study that had no control group.

Definition of historical control subject

An individual treated in the past and used in a comparison group when researchers analyze the results of a clinical study that had no control group. The use of a control, or comparison, group helps researchers determine the effects of a new treatment more accurately.

Written and maintained by James Murray Last updated July 21, 2026 Educational reference, not medical advice. Read the limitations.

For learning, not diagnosis. This glossary provides general educational information and is not a substitute for advice from a qualified healthcare professional. If you may be experiencing a medical emergency, contact local emergency services.