PM00104

Definition / meaning of PM00104

A synthetic tetrahydroisoquinoline alkaloid related to the marine natural compounds Jorumycin and the family of Renieramycins, obtained from molluscs and sponges, respectively, with potential antineoplastic activity. PM00104 reversibly binds to DNA and interferes with DNA replication, transcription, and translation. DNA binding by this agent does not trigger DNA damage checkpoint responses, hence PM00104 exhibits a reversible cytotoxicity.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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