plerixafor

Definition / meaning of plerixafor

A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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