PF-00299804

Definition / meaning of PF-00299804

A highly selective, orally bioavailabe small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. PF-00299804 specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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