paclitaxel-loaded polymeric micelle

Definition / meaning of paclitaxel-loaded polymeric micelle

A biodegradable poly(ethylene glycol)-poly(D,L-lactide) copolymer miceller nanoparticle-entrapped formulation of paclitaxel with antineoplastic activity. Paclitaxel promotes microtubule assembly and prevents depolymerization, thus interfering with normal mitosis. The copolymer residue increases the water-solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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