pNGVL4a-Sig / E7(detox) / HSP70 DNA vaccine

Definition / meaning of pNGVL4a-Sig / E7(detox) / HSP70 DNA vaccine

An antigen-specific DNA cancer vaccine consisting of the coding sequences of a signal peptide (pNGVL4a-Sig), a detox form of the human papillomavirus type 16 (HPV-16) antigen E7, and the heat shock protein 70 (HSP70). Upon administration, this vaccine may generate potent cytotoxic CD8(+) T-cell responses against E7-expressing tumor cells, resulting in tumor cell death.

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