iodine I 125 anti-EGFR-425 monoclonal antibody

Definition / meaning of iodine I 125 anti-EGFR-425 monoclonal antibody

A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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