HSV-1 HF10

Definition / meaning of HSV-1 HF10

A non-engineered, naturally oncolytic, replication-competent spontaneous herpes simplex virus (HSV) type I mutant variant. Upon intratumoral injection, HSV1 HF10 transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. In addition, this agent may increase host immune responses that may kill non-infected tumor cells.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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