maximum tolerated dose

Definition / meaning of maximum tolerated dose

The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by testing increasing doses on different groups of people until the highest dose with acceptable side effects is found. Also called MTD.

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Find More About 'maximum tolerated dose'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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