allogeneic GM-CSF-secreting breast cancer vaccine

Definition / meaning of allogeneic GM-CSF-secreting breast cancer vaccine

An allogenic vaccine consisting of irradiated breast cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene. Upon vaccination, the genetically modified cells secrete GM-CSF, thereby potentiating a tumor-specific T cell response against breast cancer cell-asociated antigens.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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